How CBD Works in Pain Management

The latest research shows that CBD can help manage pain by enhancing the body's natural endocannabinoids and interacting with other receptors. The endocannabinoid system (ECS) is a vital cell-signalling system in our bodies that helps maintain balance (homeostasis) by regulating mood, pain, appetite, and immune response.

Discovered in the early 1990s, the ECS includes endocannabinoids, receptors, and enzymes. Endocannabinoids, like anandamide and 2-AG, are natural molecules produced by our bodies. They bind to cannabinoid receptors (CB1 and CB2) to help regulate various functions.

CB1 receptors are mostly found in the brain and central nervous system, where they influence pain, memory, and mood. CB2 receptors are located in peripheral organs and immune cells, affecting inflammation and immune responses.

Cannabis interacts with the ECS through its main compounds, THC (tetrahydrocannabinol) and CBD (cannabidiol). THC binds directly to CB1 receptors, creating psychoactive effects like euphoria and altered perception, which also help relieve pain and stimulate appetite.

CBD works differently. Instead of binding directly to CB1 or CB2 receptors, it influences them to increase endocannabinoid levels, boosting their natural effects. CBD also interacts with other receptors, such as serotonin and vanillin receptors, providing additional benefits like reducing anxiety, and inflammation and offering neuroprotection. The aim of neuroprotection is to keep the cells happy, healthy and alive.

CBD engages with the endocannabinoid system to help manage pain by enhancing the body's natural endocannabinoids and interacting with other receptors. This interaction not only offers pain relief but also contributes to anti-anxiety, anti-inflammatory, and neuroprotective effects, highlighting the therapeutic benefits of CBD.